The mission of the Critical Infrastructure Protection Laboratory is to research in advanced methods of security applied within the realm of critical cyber and cyber-physical infrastructures. The focus is on the use of rigorous mathematics through formal methods to create and analyzer fault-tolerant and secure real-time distributed computing systems applied to critical infrastructure protection. The laboratory supports undergraduate, graduate, and faculty researchers. Students in the laboratory participate in the campus Center for Academic Excellence in Information Assurance and Research, the Intelligent Systems Center, and the Center for Research in Energy and Environment.

The mission of the Applied Computational Intelligence Laboratory is for students to gain many advantages, including collaboration in a work environment, continued involvement with research, the positive influence of role models and mentors, and, more often than not, an opportunity to publish. (Publishing is required for all graduate students.) The ACIL welcomes small and large business cooperative ventures in intelligent computing.

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The mission of Polaris Lab is to develop high-performance and scalable middleware for large-scale data management, storage, and analytics on cutting-edge computing systems. Driven by the actual needs from multiple science domains, research in the Polaris lab aims to address the perform issues raised by the big data challenges in real-world applications via deep collaborations with computational scientists. The research products are widely used in multiple DOE laboratories and will be validated on current and next-generation supercomputers including Summit, Aurora, and Frontier.